The 2009–2010 UCI Cyclo-cross World Cup events and season-long competition took place between 4 October 2009 and 24 January 2010, and was sponsored by the Union Cycliste Internationale (UCI).
| Date | Venue | Elite men's winner | Elite women's winner |
|---|---|---|---|
| 4 October | Treviso | Niels Albert (BEL) | Katie Compton (USA) |
| 18 October | Pilsen | Niels Albert (BEL) | No UCI World Cup race |
| 8 November | Nommay | Niels Albert (BEL) | Katie Compton (USA) |
| 28 November | Koksijde | Zdeněk Štybar (CZE) | Marianne Vos (NED) |
| 6 December | Igorre | Zdeněk Štybar (CZE) | No UCI World Cup race |
| 20 December | Kalmthout | Sven Nys (BEL) | Daphny van den Brand (NED) |
| 26 December | Heusden - Zolder | Kevin Pauwels (BEL) | Marianne Vos (NED) |
| 17 January | Roubaix | Zdeněk Štybar (CZE) | Kateřina Nash (CZE) |
| 24 January | Hoogerheide | Niels Albert (BEL) | Marianne Vos (NED) |
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